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Prof. Tom Brown publication on synthesising versatile antisense oligonucleotides with enhanced functional potential.
19th March, 2026
The latest publication by Dhara D. et al, from Prof Tom Brown's group, reports a straightforward method for synthesising antisense oligonucleotides with charge-neutral phosphotriester backbones, enabling the incorporation of diverse functional groups at multiple internal positions. These modified oligonucleotides retain strong duplex stability and splice-switching activity in vitro, with certain conjugates showing enhanced performance, highlighting their potential for improved delivery and efficacy in therapeutic applications.