News
Recent publication from Prof Tom Brown, TransNAT investigator and Chemistry work-package lead
3rd June, 2024
TransNAT investigators at the University of Oxford have developed new oligonucleotide analogues for improved cellular uptake. Led by Prof. Tom Brown, leader of the Chemistry work package in the TransNAT consortium, they envisaged a method for synthesising oligonucleotides with reduced net anionic charge, resulting in increased RNA binding affinity and nuclease resistance. These findings hold promise for enhancing the effectiveness of oligonucleotide-based therapies.